Nav1.8-expressing neurons control daily oscillations of food intake, body weight and gut microbiota in mice.

ABSTRACT: Recent evidence suggests a role of sensory neurons expressing the sodium channel Nav1.8 on the energy homeostasis control. Using a murine diphtheria toxin ablation strategy and ad libitum and time-restricted feeding regimens of control or high-fat high-sugar diets, here we further explore the function of these neurons on food intake and on the regulation of gastrointestinal elements transmitting immune and nutrient sensing.The Nav1.8+ neuron ablation increases food intake in ad libitum and time-restricted feeding, and exacerbates daily body weight variations. Mice lacking Nav1.8+ neurons show impaired prandial regulation of gut hormone secretion and gut microbiota composition, and altered intestinal immunity.Our study demonstrates that Nav1.8+ neurons are required to control food intake an

SUBMITTER: Bullich-Vilarrubias C 

PROVIDER: S-EPMC10883928 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature