Mechanism exploration and biomarker identification of glycemic deterioration in patients with diseases of the exocrine pancreas.

ABSTRACT: The damage to the endocrine pancreas among patients with diseases of the exocrine pancreas (DP) leads to reduced glycemic deterioration, ultimately resulting in diabetes of the exocrine pancreas (DEP). The present research aims to investigate the mechanism responsible for glycemic deterioration in DP patients, and to identify useful biomarkers, with the ultimate goal of enhancing clinical practice awareness. Gene expression profiles of patients with DP in this study were acquired from the Gene Expression Omnibus database. The original study defines DP patients to belong in one of three categories: non-diabetic (ND), impaired glucose tolerance (IGT) and DEP, which correspond to normoglycemia, early and late glycemic deterioration, respectively. After ensuring quality control, the discovery

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10883946 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature