Skeletal muscle status and survival among patients with advanced biliary tract cancer.

ABSTRACT:

Background

Studies have demonstrated a prognostic role of sarcopenia (i.e., loss of skeletal muscle volume and functionality) in patients with various cancer types. In patients with biliary tract cancer, the quantity and quality of skeletal muscles and their serial changes have not been fully investigated in relation to survival outcomes.

Methods

We identified 386 patients with unresectable or recurrent biliary tract cancer and calculated skeletal muscle index (SMI) and skeletal muscle density (SMD) to estimate muscular quantity and quality, respectively, based on computed tomography images. Using the Cox regression model with adjustment for potential confounders, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for progression-free survival (PFS) and ove

SUBMITTER: Takaoka S 

PROVIDER: S-EPMC10884055 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature