Bacteroidaceae, Bacteroides, and Veillonella: emerging protectors against Graves' disease.

ABSTRACT:

Background

Graves' disease (GD) is the most common cause of hyperthyroidism, and its pathogenesis remains incompletely elucidated. Numerous studies have implicated the gut microbiota in the development of thyroid disorders. This study employs Mendelian randomization analysis to investigate the characteristics of gut microbiota in GD patients, aiming to offer novel insights into the etiology and treatment of Graves' disease.

Methods

Two-sample Mendelian randomization (MR) analysis was employed to assess the causal relationship between Graves' disease and the gut microbiota composition. Gut microbiota data were sourced from the international consortium MiBioGen, while Graves' disease data were obtained from FINNGEN. Eligible single nucleotide polymorphisms (SNPs) were selected

SUBMITTER: Liu S 

PROVIDER: S-EPMC10884117 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature