CMR reveals myocardial damage from cardiotoxic oncologic therapies in breast cancer patients.

ABSTRACT:

Background

Breast cancer is a common and increasingly treatable disease. However, survivors have a significantly elevated risk of cardiac events afterwards. This study aimed to characterise cardiac changes during cardiotoxic cancer therapy using cardiovascular magnetic resonance (CMR) imaging.

Methods

This study involved 34 patients with histologically proven breast cancer and planned cardiotoxic therapy. All patients underwent CMR before starting therapy, and 6 and 12 months thereafter. The CMR protocol included volumetric and functional analyses, parametric mapping, and deformation analysis using feature tracking. As the control group, 10 healthy female volunteers were scanned using the same protocol.

Results

With therapy, there was a significant reduction of left v

SUBMITTER: Kersten J 

PROVIDER: S-EPMC10884136 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature