Glomerular filtration rate measurement during platinum treatment for urothelial carcinoma: optimal methods for clinical practice.

ABSTRACT:

Background

We assessed the accuracy of four estimated glomerular filtration rate (eGFR) methods: MDRD, Cockcroft-Gault, CKD-EPI, and Wright.

Method

The four methods were compared to measure GFR (mGFR) in patients with urothelial urinary tract cancer (T2-T4bNxMx) receiving platinum-based chemotherapy at Rigshospitalet, Copenhagen, from January 2019 to December 2021. Using standardized assays, creatinine values were measured, and mGFR was determined using Technetium-99 m diethylenetriaminepentaacetic acid (Tc-99 m-DTPA) or Cr-51-ethylenediaminetetraacetic acid (Cr-51-EDTA) plasma clearance. Patients (n = 146) with both mGFR and corresponding creatinine values available were included (n = 345 measurements).

Results

The CKD-EPI method consistently demonstrated superior ac

SUBMITTER: Stormoen DR 

PROVIDER: S-EPMC10884137 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature