SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C.

ABSTRACT:

Background

Recent infection with SARS‑CoV‑2 in children has been associated with multisystem inflammatory syndrome in children (MIS-C). SARS‑CoV‑2 has undergone different mutations. Few publications exist about specific variants and their correlation with the severity of MIS-C.

Methods

This was a single-center, retrospective study including all patients admitted with MIS-C at Rady Children's Hospital-San Diego between May 2020 and March 2022. Local epidemiologic data, including viral genomic information, were obtained from public records. Demographics, clinical presentation, laboratory values, and outcomes were obtained from electronic medical records.

Results

The analysis included 104 pediatric patients. Four MIS-C waves were identified. Circulating variants in San D

SUBMITTER: Moreno Rojas AF 

PROVIDER: S-EPMC10884140 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature