Preoperative serum cortisone levels are associated with cognition in preschool-aged children with tetralogy of Fallot after corrective surgery: new evidence from human populations and mice.

ABSTRACT:

Background

Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Children with TOF would be confronted with neurological impairment across their lifetime. Our study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with TOF.

Methods

We used mass spectrometry (MS) technology to assess the levels of serum metabolites, Wechsler preschool and primary scale of intelligence-Fourth edition (WPPSI-IV) index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging (MRI) to detect cortical morphological changes.

Results

Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index o

SUBMITTER: Ma SY 

PROVIDER: S-EPMC10884142 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature