Causality of unsaturated fatty acids and psoriasis a Mendelian randomization study.

ABSTRACT:

Background

Many observational studies have identified a link between unsaturated fatty acids and psoriasis. However, they contain reverse causality and confounding factors, and there is no definite causal study between unsaturated fatty acids and psoriasis.

Objectives

Analysis of causality between unsaturated fatty acids and psoriasis by Mendelian randomization.

Methods

We used IEU Open GWAS Project, omega-3 PUFA and omega-6 PUFA data from 114,999 subjects, MUFA data from 13,535 subjects, and psoriasis data from 4,510 cases and 212,242 controls were included. We employed the inverse-variance weighted (IVW) method as the primary analytical approach and four additional MR methods. Moreover, we performed heterogeneity and horizontal pleiotropy assessments using Cochrane'

SUBMITTER: Li J 

PROVIDER: S-EPMC10884181 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature