Skeletal muscle mitochondrial capacity in patients with statin-associated muscle symptoms (SAMS).

ABSTRACT:

Objective

The objective of this article is to evaluate near-infrared spectroscopy (NIRS), a non-invasive technique to assess tissue oxygenation and mitochondrial function, as a diagnostic tool for statin-associated muscle symptoms (SAMS).

Methods

We verified SAMS in 39 statin-treated patients (23 women) using a double-blind, placebo-controlled, cross-over protocol. Subjects with suspected SAMS were randomised to simvastatin 20 mg/day or placebo for 8 weeks, followed by a 4-week no treatment period and then assigned to the alternative treatment, either simvastatin or placebo. Tissue oxygenation was measured before and after each statin or placebo treatment using NIRS during handgrip exercise at increasing intensities of maximal voluntary contraction (MVC).

Results

44%

SUBMITTER: Mangone LA 

PROVIDER: S-EPMC10884190 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature