AIRR-C IG Reference Sets: curated sets of immunoglobulin heavy and light chain germline genes.

ABSTRACT:

Introduction

Analysis of an individual's immunoglobulin (IG) gene repertoire requires the use of high-quality germline gene reference sets. When sets only contain alleles supported by strong evidence, AIRR sequencing (AIRR-seq) data analysis is more accurate and studies of the evolution of IG genes, their allelic variants and the expressed immune repertoire is therefore facilitated.

Methods

The Adaptive Immune Receptor Repertoire Community (AIRR-C) IG Reference Sets have been developed by including only human IG heavy and light chain alleles that have been confirmed by evidence from multiple high-quality sources. To further improve AIRR-seq analysis, some alleles have been extended to deal with short 3' or 5' truncations that can lead them to be overlooked by alignment utili

SUBMITTER: Collins AM 

PROVIDER: S-EPMC10884231 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature