Sex-specific nociceptor modulation of the apical periodontitis transcriptome.

ABSTRACT: Introduction: Apical periodontitis (AP) is a painful disease that develops quickly following dental infections and is primarily characterized by robust inflammation surrounding the tissues of the affected tooth, resulting in disruption of bone homeostasis and periradicular bone loss. Moreover, there are distinct clinical presentations, symptoms, and responses to AP treatment between male and female subjects, creating a desperate need to further understand the sex-specific mechanisms of AP. Methods: With the growing evidence that nociceptors modulate AP development, we utilized RNA sequencing in nociceptor-ablated (Nav1.8 ^cre+/-, diphtheria toxin A^lox+/-) transgenic mice to study the nociceptor regulation of the periapical lesion transcriptome using a rod

SUBMITTER: Lillis KV 

PROVIDER: S-EPMC10884291 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature