Dynamics of antiphase bursting modulated by the inhibitory synaptic and hyperpolarization-activated cation currents.

ABSTRACT: Antiphase bursting related to the rhythmic motor behavior exhibits complex dynamics modulated by the inhibitory synaptic current (I_syn), especially in the presence of the hyperpolarization-activated cation current (I_h). In the present paper, the dynamics of antiphase bursting modulated by the I_h and I_syn is studied in three aspects with a theoretical model. Firstly, the I_syn and the slow I_h with strong strength are the identified to be the necessary conditions for the antiphase bursting. The dependence of the antiphase bursting on the two currents is different for low (escape mode) and high (release mode) threshold voltages (V_th) of the inhibitory synapse. Secondly,

SUBMITTER: Guan L 

PROVIDER: S-EPMC10884300 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature