Kinetic ¹⁸F-FDG PET/CT imaging of hepatocellular carcinoma: a dual input four-compartment model.

ABSTRACT:

Background

The endoplasmic reticulum plays an important role in glucose metabolism and has not been explored in the kinetic estimation of hepatocellular carcinoma (HCC) via 18F-fluoro-2-deoxy-D-glucose PET/CT.

Methods

A dual-input four-compartment (4C) model, regarding endoplasmic reticulum was preliminarily used for kinetic estimation to differentiate 28 tumours from background liver tissue from 24 patients with HCC. Moreover, parameter images of the 4C model were generated from one patient with negative findings on conventional metabolic PET/CT.

Results

Compared to the dual-input three-compartment (3C) model, the 4C model has better fitting quality, a close transport rate constant (K₁) and a dephosphorylation rate constant (k₆/k₄), a

SUBMITTER: Wang T 

PROVIDER: S-EPMC10884391 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature