Sepsis and obesity: a scoping review of diet-induced obesity murine models.

ABSTRACT:

Background

Sepsis, the life-threatening host response to infection, is a major cause of mortality. Obesity increases vulnerability to sepsis; however, some degree of obesity may be protective, called the "obesity paradox". This scoping review systematically maps the literature on outcomes associated with diet-induced obesity and sepsis-induced organ injury, focusing on non-transgenic murine models.

Methods

A literature search of primary articles was conducted from database inception to June 2023. Eligible articles compared diet-induced obesity to non-obese mice in sepsis models involving live pathogens. Two reviewers screened articles and extracted data on obesogenic and sepsis models utilized, and organ injury outcomes, including physiological dysfunction, histological alte

SUBMITTER: Eng M 

PROVIDER: S-EPMC10884395 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature