Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections.

ABSTRACT: Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine and copper, the ultrasound-activated piezo-hot carriers transfer easily to copper by polydopamine. It boosts reactive oxygen species production by piezoelectrics, and facilitates the interconversion between Cu2⁺ and Cu⁺ to promote hydroxyl radical generation via Cu⁺ -catalyzed chemodynamic reactions. Finally, the elevated reactive oxygen species cause bacterial membrane structu

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10884398 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature