Neural sensitivity following stress predicts anhedonia symptoms: a 2-year multi-wave, longitudinal study.

ABSTRACT: Animal models of depression show that acute stress negatively impacts functioning in neural regions sensitive to reward and punishment, often manifesting as anhedonic behaviors. However, few human studies have probed stress-induced neural activation changes in relation to anhedonia, which is critical for clarifying risk for affective disorders. Participants (N = 85, 12-14 years-old, 53 female), oversampled for risk of depression, were administered clinical assessments and completed an fMRI guessing task during a baseline (no-stress) period to probe neural response to receipt of rewards and losses. After the initial task run of the fMRI guessing task, participants received an acute stressor and then, were re-administered the guessing task. Including baseline, participants provided up to 10

SUBMITTER: Kirshenbaum JS 

PROVIDER: S-EPMC10884408 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature