Analysis of the role of PANoptosis in seizures via integrated bioinformatics analysis and experimental validation.

ABSTRACT:

Background

Epilepsy is recognized as the most common chronic neurological condition among children, and hippocampal neuronal cell death has been identified as a crucial factor in the pathophysiological processes underlying seizures. In recent studies, PANoptosis, a newly characterized form of cell death, has emerged as a significant contributor to the development of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. PANoptosis involves the simultaneous activation of pyroptosis, apoptosis, and necroptosis within the same population of cells. However, its specific role in the context of seizures remains to be fully elucidated. Further investigation is required to uncover the precise involvement of PANoptosis in the p

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10884430 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature