Diphenyl ethers from the cultured lichen mycobiont of Graphis handelii Zahlbr.

ABSTRACT:

Purpose

Cultured lichen mycobionts are valuable sources of new natural compounds. Mycobiont of Graphis handelii growing in Vietnam was isolated, cultivated and chemically investigated. The crude extract of this cultured mycobiont showed potent alpha-glucosidase inhibition with an IC₅₀ value of 50 μg/mL.

Methods

Multiple chromatographic methods were applied to the extract to isolate compounds. The combination of Nuclear Magnetic Resonance analysis and high-resolution mass spectroscopy determined their chemical structures. Electrophilic bromination/chlorination was applied to obtain new derivatives using NaBr/H₂O₂ and NaCl/H₂O₂ reagents. Compounds were evaluated for enzyme inhibitory activities, including alpha-gluc

SUBMITTER: Tran TM 

PROVIDER: S-EPMC10884431 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature