Causal effects of gut microbiota on the risk of urinary tract stones: A bidirectional two-sample mendelian randomization study.

ABSTRACT:

Background

Recent studies increasingly suggest notable changes in both the quantity and types of gut microbiota among individuals suffering from urinary tract stones. However, the causal relationship between GMB and urinary tract stone formation remains elusive, which we aim to further investigate in this research through Mendelian Randomization (MR) analysis.

Materials and methods

Single nucleotide polymorphisms (SNPs) associated with the human GMB were selected from MiBioGen International Consortium GWAS dataset. Data on urinary tract stone-related traits and associated SNPs were sourced from the IEU Open GWAS database. To investigate the causal relationships between gut microbiota and urinary tract stones, Mendelian Randomization (MR) was applied using genetic variants as

SUBMITTER: Pan Y 

PROVIDER: S-EPMC10884461 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature