Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates.

ABSTRACT: Influenza A virus (IAV) employs multiple strategies to manipulate cellular mechanisms and support proper virion formation and propagation. In this study, we performed a detailed analysis of the interplay between IAV and the host cells' proteostasis throughout the entire infectious cycle. We reveal that IAV infection activates the inositol requiring enzyme 1 (IRE1) branch of the unfolded protein response, and that this activation is important for an efficient infection. We further observed the accumulation of virus-induced insoluble protein aggregates, containing both viral and host proteins, associated with a dysregulation of the host cell RNA metabolism. Our data indicate that this accumulation is important for IAV propagation and favors the final steps of the infection cycle, more specif

SUBMITTER: Marques M 

PROVIDER: S-EPMC10884513 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature