Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake.

ABSTRACT:

Background

Metabolomics has the potential to enhance dietary assessment by revealing objective measures of many aspects of human food intake. Although metabolomics studies indicate that hundreds of metabolites are associated with dietary intake, correlations have been modest (e.g., r < 0.50), and few have been evaluated in controlled feeding studies.

Objectives

The aim of this study was to evaluate associations between metabolites and weighed food and beverage intake in a controlled feeding study of habitual diet.

Methods

Healthy postmenopausal females from the Women's Health Initiative (N = 153) were provided with a customized 2-wk controlled diet designed to emulate their usual diet. Metabolites were measured by liquid chromatography tandem mass spectrometry in end-

SUBMITTER: Playdon MC 

PROVIDER: S-EPMC10884612 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature