Clinical and Preclinical Evidence for Gut Microbiome Mechanisms in Substance Use Disorders.

ABSTRACT: Substance use disorders are a set of recalcitrant neuropsychiatric conditions that cause tremendous morbidity and mortality and are among the leading causes of loss of disability-adjusted life years worldwide. While each specific substance use disorder is driven by problematic use of a different substance, they all share a similar pattern of escalating and out-of-control substance use, continued use despite negative consequences, and a remitting/relapsing pattern over time. Despite significant advances in our understanding of the neurobiology of these conditions, current treatment options remain few and are ineffective for too many individuals. In recent years, there has been a rapidly growing body of literature demonstrating that the resident population of microbes in the gastrointestinal

SUBMITTER: Hofford RS 

PROVIDER: S-EPMC10884738 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature