Gastric and duodenal cancer in individuals with Lynch syndrome: a nationwide cohort study.

ABSTRACT:

Background

Lynch syndrome increases the risk of gastric cancer (GC) and duodenal cancer (DC), particularly in individuals with MLH1 and MSH2 pathogenic variants (PVs). To provide further insight into whether, and from what age, esophagogastroduodenoscopy (EGD) surveillance may be beneficial, we evaluated the cumulative incidence and tumour characteristics of GC and DC in a large nationwide cohort of Dutch individuals with LS.

Methods

For this retrospective nationwide cohort study, clinical data of individuals with LS registered at the Dutch Hereditary Cancer Registry were matched with pathology reports filed by the Dutch Pathology registry. All individuals registered between Jan 1, 1989 and Dec 31, 2021 with proven or putative PVs in one of the mismatch repair

SUBMITTER: Caspers IA 

PROVIDER: S-EPMC10884743 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature