Human metapneumovirus respiratory infection affects both innate and adaptive intestinal immunity.

ABSTRACT:

Introduction

Respiratory infections are one of the leading causes of morbidity and mortality worldwide, mainly in children, immunocompromised people, and the elderly. Several respiratory viruses can induce intestinal inflammation and alterations in intestinal microbiota composition. Human metapneumovirus (HMPV) is one of the major respiratory viruses contributing to infant mortality in children under 5 years of age worldwide, and the effect of this infection at the gut level has not been studied.

Methods

Here, we evaluated the distal effects of HMPV infection on intestinal microbiota and inflammation in a murine model, analyzing several post-infection times (days 1, 3, and 5). Six to eight-week-old C57BL/6 mice were infected intranasally with HMPV, and mice inoculated with a

SUBMITTER: Sepulveda-Alfaro J 

PROVIDER: S-EPMC10884822 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature