Metabolomics comparison of metabolites and functional pathways in the SH-SY5Y cell model of Parkinson's disease under PEMF exposure.

ABSTRACT:

Objective

PEMF is an emerging technique in the treatment of Parkinson's disease (PD) due to its potential improvement of movement speed. The aim of this study was to investigate the metabolic profiles of pulsed electromagnetic fields (PEMFs) in an SH-SY5Y cell model of PD.

Methods

The SH-SY5Y cell model of PD was induced by 1-methyl-4-phenylpyridinium (MPP⁺). Liquid chromatography mass spectrometry (LC‒MS)-based untargeted metabolomics was performed to examine changes in the PD cell model with or without PEMF exposure. We conducted KEGG pathway enrichment analysis to explore the potentially related pathways of the differentially expressed metabolites.

Results

A total of 275 metabolites were annotated, and 27 significantly different metabolites were found be

SUBMITTER: Zhu LN 

PROVIDER: S-EPMC10884933 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature