Appraising the causal association between Crohn's disease and breast cancer: a Mendelian randomization study.

ABSTRACT:

Background

Previous research has indicated that there may be a link between Crohn's disease (CD) and breast cancer (BC), but the causality remains unclear. This study aimed to investigate the causal association between CD and BC using Mendelian randomization (MR) analysis.

Methods

The summary data for CD (5,956 cases/14,927 controls) was obtained from the International Inflammatory Bowel Disease Genetics Consortium (IIBDGC). And the summary data for BC (122,977 cases/105,974 controls) was extracted from the Breast Cancer Association Consortium (BCAC). Based on the estrogen receptor status, the cases were classified into two subtypes: estrogen receptor-positive (ER⁺) BC and estrogen receptor-negative (ER^-) BC. We used the inverse variance weighted method

SUBMITTER: Yu C 

PROVIDER: S-EPMC10884953 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature