Transient Adenosine Modulates Serotonin Release Indirectly in the Dorsal Raphe Nuclei.

ABSTRACT: Rapid adenosine transiently regulates dopamine and glutamate via A₁ receptors, but other neurotransmitters, such as serotonin, have not been studied. In this study, we examined the rapid modulatory effect of adenosine on serotonin release in the dorsal raphe nuclei (DRN) of mouse brain slices by using fast-scan cyclic voltammetry. To mimic adenosine release during damage, a rapid microinjection of adenosine at 50 pmol was applied before electrical stimulation of serotonin release. Transient adenosine significantly reduced electrically evoked serotonin release in the first 20 s after application, but serotonin release recovered to baseline as adenosine was cleared from the slice. The continuous perfusion of adenosine did not change the evoked serotonin release. Surprisingly, the

SUBMITTER: Shrestha K 

PROVIDER: S-EPMC10885004 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature