Identification of a Chondrocyte-Specific Enhancer in the Hoxc8 Gene.

ABSTRACT: Hox genes encode transcription factors whose roles in patterning animal body plans during embryonic development are well-documented. Multiple studies demonstrate that Hox genes continue to act in adult cells, in normal differentiation, in regenerative processes, and, with abnormal expression, in diverse types of cancers. However, surprisingly little is known about the regulatory mechanisms that govern Hox gene expression in specific cell types, as they differentiate during late embryonic development, and in the adult organism. The murine Hoxc8 gene determines the identity of multiple skeletal elements in the lower thoracic and lumbar region and continues to play a role in the proliferation and differentiation of cells in cartilage as the skeleton matures. This s

SUBMITTER: Cormier SA 

PROVIDER: S-EPMC10885077 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature