Modulation of Gold Nanoparticle Ligand Structure-Dynamic Relationships Probed Using Solution NMR.

ABSTRACT: Ligand dynamics plays a critical role in the chemical and biological properties of gold nanoparticles (AuNPs). In this study, ligands featuring hydrophobic alkanethiol interiors and hydrophilic shells were used to systematically examine the effects of ligand headgroups on the ligand dynamics. Solution nuclear magnetic resonance (NMR) spectroscopy provided quantitative insight into the monolayer ligand dynamics. Notably, the introduction of hydrophobic moieties to the cationic headgroups significantly decreased ligand conformational mobility; however, variations in hydrophobicity among these moieties had a limited effect on this reduction. Further examination of ligand dynamics under various physiological conditions, including ionic strength and temperature, showed that ligands bound to the

SUBMITTER: Huang R 

PROVIDER: S-EPMC10885325 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature