Mannose-binding lectin gene polymorphism in psoriasis and vitiligo: an observational study and computational analysis.

ABSTRACT:

Introduction

Psoriasis and vitiligo are inflammatory autoimmune skin disorders with remarkable genetic involvement. Mannose-binding lectin (MBL) represents a significant immune molecule with one of its gene variants strongly linked to autoimmune diseases. Therefore, in this study, we investigated the role of the MBL variant, rs1800450, in psoriasis and vitiligo disease susceptibility.

Methods

The study comprised performing in silico analysis, performing an observational study regarding psoriasis patients, and performing an observational study regarding vitiligo patients. Various in silico tools were used to investigate the impact of the selected mutation on the function, stability, post-translational modifications (PTMs), and secondary structures of the protein

SUBMITTER: Behairy MY 

PROVIDER: S-EPMC10885344 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature