Causal effects of endometriosis on SLE, RA and SS risk: evidence from meta-analysis and Mendelian randomization.

ABSTRACT:

Background

Endometriosis is an underdiagnosed disorder that affects an estimated 6-10% of women of reproductive age. Endometriosis has been reported in epidemiological studies to be associated with autoimmune diseases. However, the relationship remains controversial.

Methods

A meta-analysis of observational studies was undertaken to evaluate the risk of autoimmune diseases in patients with endometriosis. The relevant studies were retrieved via the databases Medline, Embase and Web of Science until July 20, 2023. Mendelian randomization (MR) was subsequently utilized to scrutinize the causal influence of genetic predisposition toward endometriosis on three autoimmune diseases.

Results

The meta-analysis findings revealed a relationship between endometriosis and the onse

SUBMITTER: Tang T 

PROVIDER: S-EPMC10885476 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature