An immunogenic cell death-related gene expression signature in predicting prognosis of pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Immunogenic cell death (ICD) has been identified as regulated cell death, which is sufficient to activate the adaptive immune response. This study aimed to research ICD-related genes and create a gene model to predict pancreatic ductal adenocarcinoma (PAAD) patients' prognosis.

Methods

The RNA sequencing and clinical data were downloaded from the TGCA and GEO databases. The PAAD samples were classified into two subtypes based on the expression levels of ICD-related genes using consensus clustering. Based on the differentially expressed genes (DEGs), a prognostic scoring model was constructed using LASSO regression and Cox regression, and the scoring model was used to predict the prognosis of PAAD patients. Moreover, colony formation assay was performed to confirm

SUBMITTER: Wang X 

PROVIDER: S-EPMC10885505 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature