Standard-Volume Is As Effective As High-Volume Plasma Exchange for Patients With Acute Liver Failure.

ABSTRACT:

Background/aims

Acute liver failure (ALF) is associated with fatal outcomes without liver transplantation. Two randomized studies reported standard volume (SV) and high volume (HV) plasma exchange (PLEX) as effective therapeutic modalities for patients with ALF. However, no studies have compared the safety and efficacy of SV with HV PLEX, which we aimed to assess.

Methods

This retrospective study included patients with ALF admitted between March 2021 and March 2023 who underwent PLEX. All patients underwent HV PLEX until May 2022, and then thereafter, SV PLEX was performed. The objectives of the study were to compare transplant-free survival (TFS) at 30 days, efficacy in reducing severity scores, biochemical variables, and adverse events between SV (total plasma volume x 1)

SUBMITTER: Kulkarni AV 

PROVIDER: S-EPMC10885581 | biostudies-literature | 2024 May-Jun

REPOSITORIES: biostudies-literature