Radiation Therapy in the Management of Leptomeningeal Disease From Solid Tumors.

ABSTRACT:

Purpose

Leptomeningeal disease (LMD) is clinically detected in 5% to 10% of patients with solid tumors and is a source of substantial morbidity and mortality. Prognosis for this entity remains poor and treatments are palliative. Radiation therapy (RT) is an essential tool in the management of LMD, and a recent randomized trial demonstrated a survival benefit for proton craniospinal irradiation (CSI) in select patients. In the setting of this recent advance, we conducted a review of the role of RT in LMD from solid tumors to evaluate the evidence basis for RT recommendations.

Methods and materials

In November 2022, we conducted a comprehensive literature search in PubMed, as well as a review of ongoing clinical trials listed on ClinicalTrials.gov, to inform a discussion on th

SUBMITTER: Barbour AB 

PROVIDER: S-EPMC10885590 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature