Proteomic analysis of decellularized mice liver and kidney extracellular matrices.

ABSTRACT:

Background

The extracellular matrix (ECM) is a three-dimensional network of proteins that encases and supports cells within a tissue and promotes physiological and pathological cellular differentiation and functionality. Understanding the complex composition of the ECM is essential to decrypt physiological processes as well as pathogenesis. In this context, the method of decellularization is a useful technique to eliminate cellular components from tissues while preserving the majority of the structural and functional integrity of the ECM.

Results

In this study, we employed a bottom-up proteomic approach to elucidate the intricate network of proteins in the decellularized extracellular matrices of murine liver and kidney tissues. This approach involved the use of a novel, per

SUBMITTER: Diedrich AM 

PROVIDER: S-EPMC10885605 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature