Emerging Strategies for Immunotherapy of Solid Tumors Using Lipid-Based Nanoparticles.

ABSTRACT: The application of lipid-based nanoparticles for COVID-19 vaccines and transthyretin-mediated amyloidosis treatment have highlighted their potential for translation to cancer therapy. However, their use in delivering drugs to solid tumors is limited by ineffective targeting, heterogeneous organ distribution, systemic inflammatory responses, and insufficient drug accumulation at the tumor. Instead, the use of lipid-based nanoparticles to remotely activate immune system responses is an emerging effective strategy. Despite this approach showing potential for treating hematological cancers, its application to treat solid tumors is hampered by the selection of eligible targets, tumor heterogeneity, and ineffective penetration of activated T cells within the tumor. Notwithstanding, the use of li

SUBMITTER: Fernandes S 

PROVIDER: S-EPMC10885677 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature