Comparison of different algorithms for lupus anticoagulant detection: a single-center experience.

ABSTRACT:

Background

The laboratory tests for lupus anticoagulant (LA) detection comprise complex and multistep coagulation testing procedures. There is no established gold standard assay or direct comparison of algorithms as recommended by different guidelines.

Objectives

This study aimed to evaluate and compare the LA detection performance of different laboratory algorithms suggested by the existing guidelines.

Methods

The routine LA test data of 1801 plasma samples, including 188 LA-positive and 1613 LA-negative samples, were re-evaluated by applying the algorithms recommended by existing guidelines and were interpreted using various methods. Diagnostic performance indices for each LA detection algorithm were compared with those of the other algorithms. The efficacies of the

SUBMITTER: Apipongrat D 

PROVIDER: S-EPMC10885790 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature