CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis.

ABSTRACT:

Background

Cladribine has been introduced as a high-efficacy drug for treating relapsing-remitting multiple sclerosis (RRMS). Initial cohort studies showed early disease activity in the first year after drug initiation. Biomarkers that can predict early disease activity are needed.

Aim

To estimate cerebrospinal fluid (CSF) markers of clinical and radiological responses after initiation of cladribine.

Methods

Forty-two RRMS patients (30F/12M) treated with cladribine were included in a longitudinal prospective study. All patients underwent a CSF examination at treatment initiation, clinical follow-up including Expanded Disability Status Scale (EDSS) assessment, and a 3T MRI scan after 6,12 and 24 months, including the evaluation of white matter (WM) and cortical lesions

SUBMITTER: Marastoni D 

PROVIDER: S-EPMC10885800 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature