Outbreak of Pseudomonas aeruginosa High-Risk Clone ST309 Serotype O11 Featuring bla_PER-1 and qnrVC6.

ABSTRACT: Pseudomonas aeruginosa is a leading cause of hospital-acquired infections worldwide. Biofilm production, antibiotic resistance, and a wide range of virulence factors contribute to their persistence in nosocomial environments. We describe an outbreak caused by a multidrug-resistant P. aeruginosa strain in an ICU. Antibiotic susceptibility was determined and bla_PER-1 and qnrVC were amplified via PCR. Clonality was determined using PFGE and biofilm formation was studied with a static model. A combination of antibiotics was assessed on both planktonic cells and biofilms. WGS was performed on five isolates. All isolates were clonally related, resistant to ceftazidime, cefepime, amikacin, and ceftolozane-tazobactam, and harbored bla_PER-1;

SUBMITTER: Papa-Ezdra R 

PROVIDER: S-EPMC10885872 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature