Diverse Role of bla_CTX-M and Porins in Mediating Ertapenem Resistance among Carbapenem-Resistant Enterobacterales.

ABSTRACT: Among carbapenem-resistant Enterobacterales (CRE) are diverse mechanisms, including those that are resistant to meropenem but susceptible to ertapenem, adding further complexity to the clinical landscape. This study investigates the emergence of ertapenem-resistant, meropenem-susceptible (ErMs) Escherichia coli and Klebsiella pneumoniae CRE across five hospitals in San Antonio, Texas, USA, from 2012 to 2018. The majority of the CRE isolates were non-carbapenemase producers (NCP; 54%; 41/76); 56% of all NCP isolates had an ErMs phenotype. Among ErMs strains, E. coli comprised the majority (72%). ErMs strains carrying bla_CTX-M had, on average, 9-fold higher copies of bla_CTX-M than CP-ErMs strains as well as approximately 4-fold more co

SUBMITTER: Black CA 

PROVIDER: S-EPMC10885879 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature