Redox Imbalance in Nasal Epithelial Cells of Primary Ciliary Dyskinesia Patients.

ABSTRACT: Background: Primary Ciliary Dyskinesia (PCD) represents a rare condition marked by an abnormal mobility pattern of cilia and flagella, resulting in impaired mucociliary clearance. This deficiency leads to recurrent infections and persistent inflammation of the airways. While previous studies have indicated heightened oxidative stress levels in the exhaled breath condensate of pediatric PCD patients, the assessment of oxidative stress within the affected respiratory tissue remains unexplored. Aims: To assess the oxidative status of human nasal epithelial cells (NECs) in PCD patients. Methods: Thirty-five PCD patients and thirty-five healthy control subjects were prospectively included in the study. Levels of reactive oxygen species (ROS), reactive nitrogen species (RNS)

SUBMITTER: Reula A 

PROVIDER: S-EPMC10885940 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature