In Vitro Activity of "Old" and "New" Antimicrobials against the Klebsiella pneumoniae Complex.

ABSTRACT: The Klebsiella pneumoniae complex is a commonly isolated bacteria in human infections. These opportunistic pathogens pose a serious threat to public health due to their potential transmission to the human population. Resistance to carbapenems is a significant antimicrobial resistance mechanism, leading to limited therapeutic options. Therefore, the aim of this study was to evaluate the in vitro activity of fosfomycin, colistin, ceftazidime-avibactam, and meropenem-vaborbactam against multidrug-resistant K. pneumoniae complex strains. This study involved 160 strains of Gram-negative rods, comprising 138 K. pneumoniae and 22 K. variicola. The minimal inhibitory concentration of fosfomycin was estimated using the agar dilution method, and for colistin, the microdil

SUBMITTER: Sekowska A 

PROVIDER: S-EPMC10886291 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature