Piceid Octanoate Protects Retinal Cells against Oxidative Damage by Regulating the Sirtuin 1/Poly-ADP-Ribose Polymerase 1 Axis In Vitro and in rd10 Mice.

ABSTRACT: Retinitis pigmentosa is a common cause of inherited blindness in adults, which in many cases is associated with an increase in the formation of reactive oxygen species (ROS) that induces DNA damage, triggering Poly-ADP-Ribose Polymerase 1 (PARP1) activation and leading to parthanatos-mediated cell death. Previous studies have shown that resveratrol (RSV) is a promising molecule that can mitigate PARP1 overactivity, but its low bioavailability is a limitation for medical use. This study examined the impact of a synthesized new acylated RSV prodrug, piceid octanoate (PIC-OCT), in the 661W cell line against H₂O₂ oxidative stress and in rd10 mice. PIC-OCT possesses a better ADME profile than RSV. In response to H₂O₂, 661W cells pretreated with PIC-OC

SUBMITTER: Moshtaghion SM 

PROVIDER: S-EPMC10886367 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature