From Host Defense to Metabolic Signatures: Unveiling the Role of γδ T Cells in Bacterial Infections.

ABSTRACT: The growth of antibiotic-resistant bacterial infections necessitates focusing on host-derived immunotherapies. γδ T cells are an unconventional T cell subset, making up a relatively small portion of healthy circulating lymphocytes but a substantially increased proportion in mucosal and epithelial tissues. γδ T cells are activated and expanded in response to bacterial infection, having the capability to produce proinflammatory cytokines to recruit neutrophils and clear infection. They also play a significant role in dampening immune response to control inflammation and protecting the host against secondary challenge, making them promising targets when developing immunotherapy. Importantly, γδ T cells have differential metabolic states influencing their cytokine profile and subsequent inflam

SUBMITTER: Nanda N 

PROVIDER: S-EPMC10886488 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature