Brain-Derived Neurotrophic Factor in Pediatric Acquired Brain Injury and Recovery.

ABSTRACT: We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), traumatic brain injury, global cerebral ischemia, and stroke. We also summarize evidence suggesting that BDNF is (1) involved in the biological embedding of the psychosocial environment, (2) responsive to rehabilitative therapies, and (3) potentially modifiable. BDNF's unique potential as a biomarker of neuroplasticity and neural repair that is reflective of and responsive to both pre- and post-injury environmental influences separates it from traditional protein biomarkers of structural brain injury with exciting potential to advance pediatric A

SUBMITTER: Treble-Barna A 

PROVIDER: S-EPMC10886547 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature