Challenges and Promise for Glioblastoma Treatment through Extracellular Vesicle Inquiry.

ABSTRACT: Glioblastoma (GB) is a rare but extremely aggressive brain tumor that significantly impacts patient outcomes, affecting both duration and quality of life. The protocol established by Stupp and colleagues in 2005, based on radiotherapy and chemotherapy with Temozolomide, following maximum safe surgical resection remains the gold standard for GB treatment; however, it is evident nowadays that the extreme intratumoral and intertumoral heterogeneity, as well as the invasiveness and tendency to recur, of GB are not compatible with a routine and unfortunately ineffective treatment. This review article summarizes the main challenges in the search for new valuable therapies for GB and focuses on the impact that extracellular vesicle (EV) research and exploitation may have in the field. EVs are nat

SUBMITTER: Liguori GL 

PROVIDER: S-EPMC10886570 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature