MARCKS Inhibition Alters Bovine Neutrophil Responses to Salmonella Typhimurium.

ABSTRACT: Neutrophils are innate immune cells that respond quickly to sites of bacterial infection and play an essential role in host defense. Interestingly, some bacterial pathogens benefit from exuberant neutrophil inflammation. Salmonella is one such pathogen that can utilize the toxic mediators released by neutrophils to colonize the intestine and cause enterocolitis. Because neutrophils can aid gut colonization during Salmonella infection, neutrophils represent a potential host-directed therapeutic target. Myristoylated alanine-rich C-kinase substrate (MARCKS) is an actin-binding protein that plays an essential role in many neutrophil effector responses. We hypothesized that inhibition of MARCKS protein would alter bovine neutrophil responses to Salmonella Typhimurium (STm)

SUBMITTER: Conley HE 

PROVIDER: S-EPMC10886653 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature