Effects of Targeted Memory Reactivation on Cortical Networks.

ABSTRACT: Sleep is a complex physiological process with an important role in memory consolidation characterised by a series of spatiotemporal changes in brain activity and connectivity. Here, we investigate how task-related responses differ between pre-sleep wake, sleep, and post-sleep wake. To this end, we trained participants on a serial reaction time task using both right and left hands using Targeted Memory Reactivation (TMR), in which auditory cues are associated with learned material and then re-presented in subsequent wake or sleep periods in order to elicit memory reactivation. The neural responses just after each cue showed increased theta band connectivity between frontal and other cortical regions, as well as between hemispheres, in slow wave sleep compared to pre- or post-sleep wake. Thi

SUBMITTER: Santamaria L 

PROVIDER: S-EPMC10886727 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature