Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells.

ABSTRACT: Low-grade inflammation is closely linked to obesity and obesity-related comorbidities; therefore, immune cells have become an important topic in obesity research. Here, we performed a deep phenotypic characterization of circulating T cells in people with obesity, using flow cytometry. Forty-one individuals with obesity (OB) and clinical criteria for bariatric surgery were enrolled in this study. We identified and quantified 44 different circulating T cell subsets and assessed their activation status and the expression of immune-checkpoint molecules, immediately before (T1) and 7-18 months after (T2) the bariatric surgery. Twelve age- and sex-matched healthy individuals (nOB) were also recruited. The OB participants showed higher leukocyte counts and a higher percentage of neutrophils. The

SUBMITTER: Barbosa P 

PROVIDER: S-EPMC10886753 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature